What factors influence bioavailability?

Article by: Antonio Meza | Last update: April 10, 2022
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The most important factors that influence the bioavailability of drugs administered orally are the following: physical-chemical properties of the drug (for example, pH, ionization, particle size, etc.), formulation of the drug (for example, example, excipients), interactions with other …

What factors are taken into account to calculate the bioavailability of a drug?

Bioavailability is usually estimated by determining the area under the plasma concentration-time curve (see figure Representation of the relationship between plasma concentration and time after oral administration of a single dose of a hypothetical drug).

How is bioavailability determined?

The measurement of the amount of drug absorbed is estimated with the experimental data of the plasma concentration profiles as a function of time and from these the area under the plasma concentration curve (AUC) is calculated.

What factors influence absorption?

The factors that influence drug absorption are: route of administration, ability of the drug to dissolve, blood supply to the point of administration, body surface area, and lipid solubility of the drug.

What decreases bioavailability?

Low bioavailability is more common with poorly water-soluble and slowly absorbed oral dosage forms of drugs. Another important cause of low bioavailability is not having enough time in the digestive tract for absorption to occur.

29 related questions found

What factors affect the action of a drug?

    Genetic composition. …Age.Body size.Consumption of other drugs and dietary supplements (such as herbal medicines. …Consumption of food (including beverages)Presence of diseases (such as kidney or liver disease)

What is bioavailability examples?

Bioavailability is the degree and speed with which an active form (the drug or one of its metabolites) enters the circulation, and thus reaches its site of action.

What is absorption and what factors affect it?

Absorption refers to the passage of the drug through cell membranes. This step will depend on factors such as liposolubility or the degree of ionization, in addition to other factors such as the characteristics of the pharmaceutical preparation, the site of absorption, and presystemic elimination phenomena.

What are the absorption mechanisms?

The absorption mechanisms of the active principles, in order of importance, are the following: a) passive diffusion; b) convective transport; c) active transport; d) facilitated transportation; e) ion-pair transport; and f) endosytosis or pinosytosis, which is the transport of particles.

What are absorption processes?

The process by which nutrients are incorporated from the digestive system into the blood so that the body can use them.

What is drug bioavailability?

Bioavailability is a measure of the drug concentration that reaches the general circulation in a given period. It is an indirect measure of drug concentration at the site of action.

How important is it to know the bioavailability of a drug?

Differences in bioavailability between different formulations of the same drug may be of clinical importance; therefore, it is essential to know whether or not different formulations of a drug are equivalent.

How many types of absorption are there?

Drug absorption

    Passive diffusion.Passive facilitated diffusion.Active transport.Pinocytosis.

What are the mechanisms involved in the absorption of substances in the digestive tract?

The nutrient absorption process occurs mainly and with extraordinary efficiency through the walls of the small intestine, where most of the water, alcohol, sugars, minerals and water-soluble vitamins are absorbed, as well as the digestion products of proteins, fats and carbohydrates…

What is the mechanism of absorption using fat-soluble drugs?

Since the cell membrane is lipid in nature, lipid-soluble molecules diffuse more rapidly. Small molecules tend to cross membranes faster than larger ones.

What is absorption in nursing?

Absorption is the part of pharmacokinetics that studies the entry of drugs into the body from the place where they are administered.

What is drug absorption?

The absorption of a drug is its passage into the bloodstream after being administered. (See also Introduction to Drug Delivery and Kinetics. Drug kinetics (pharmacokinetics) describes how the body uses a drug…

What factors affect the bioavailability of drugs?

The most important factors that influence the bioavailability of drugs administered orally are the following: physical-chemical properties of the drug (for example, pH, ionization, particle size, etc.), formulation of the drug (for example, example, excipients), interactions with other …

What type of drug is digoxin?

Pharmacotherapeutic group: digitalis glycosides. ATC code: C01AA. Digoxin increases myocardial contractility by direct activity. It is a digitalis cardiotonic with a narrow therapeutic margin that makes it necessary to individualize the dose and monitor plasma levels.

Which pathway is absent?

The topical route uses the skin and mucous membranes for drug administration. Thus, this includes the conjunctival, oral, and urogenital mucosa. The characteristic of this route is that the effect is fundamentally sought at a local level, not interested in the absorption of the active ingredients.

What is absorption and what are the mechanisms by which it can be carried out?

The absorption mechanisms are part of the process of adaptation and acceptance of our body towards various drugs that we enter our body. The set of processes to which a drug is subjected from its administration in the body to its elimination are summarized with the acronym LADME.

What is passive absorption?

1. Passive absorption (osmosis). How plants can obtain water down a concentration gradient without spending energy.

What is bioavailability and bioequivalence?

Bioequivalence must be demonstrated through the corresponding clinical trials. And by bioavailability is meant the amount of active ingredient and the speed with which it passes from the pharmaceutical form in which it is formulated to the general blood circulation.

What is the process of intestinal absorption?

Absorption is the passage of nutrients that have been degraded from the lumen of the intestinal tube to the internal environment.

What is absorption in physics?

In terms of classical electromagnetism, absorption is the phenomenon by which non-transparent materials (α ≠ 0) attenuate any electromagnetic wave that passes through them, the absorbed energy is converted into heat (Joule effect).

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